Estradiol Cream

Once your consultation and health questionnaire is reviewed and approved. Your prescription is sent directly to one of our pharmaceutical partners. Processing and shipping times can vary. Typically, we see our customers receiving their treatments within 3-5 days of approval.

Yes. When your order ships, you will receive a text or email with a tracking number directly from the pharmacy fulfilling your treatment. Locate your pharmacy via Patient Portal / Prescriptions. You can contact them for status updates at any time.

• If the carrier marks your package as delivered but you haven’t received it, contact support immediately. We’ll open a claim directly with the pharmacy partner on your behalf.
• For damaged items, retain all packaging and contents, then reach out to support. We will work on your behalf with the pharmacy to resolve the issue.

 We process orders 24/7. However, most carriers do not deliver on major U.S. holidays. If you need your treatment by a specific date, plan accordingly and order well in advance

 Yes, if your order hasn’t shipped. Contact support within two hours of placing your order to update your address. Once the package is in transit, address changes cannot be made.

All packages are mailed in plain boxes from our pharmaceutical partners. Your invoice and shipping notifications use neutral language. Your treatment or RX will never be on the exterior of the box.

We process refunds quickly and automatically for any treatment if deemed ineligible after your consultation. However, refund timing can vary based on your bank or payment provider, and it may take up to one week to appear in your account.

We cannot accept refunds for products that have already been processed by our pharmacies due to safety and regulatory reasons. 

Send us an email to support@plutocare.us. Expect a response within one business day.

If you refuse delivery or return the unopened kit it is not refundable due to safety and regulatory reasons. 

Not at this time. All refunds will be processed and refunded to your payment method.

Yes! Ketamine has been approved by the FDA in 1970 for anesthesia. Over the past 50+ years, it has been administered to millions of patients worldwide with a well-characterized safety record.Researchers first published case reports and trials in 2000 demonstrating rapid antidepressant effects in treatment-resistant depression (TRD) patients, and subsequent studies throughout the 2000s expanded its off-label use for depression, PTSD, and other disorders. Ketamine has been FDA-approved as an anesthetic since 1970. In 2019, the FDA approved esketamine (a ketamine derivative) for treatment-resistant depression. PlutoCare prescribers may use ketamine off-label when clinically appropriate. Hundreds of thousands of patients have undergone off-label ketamine treatment worldwide over the past two decades. Our providers will review all potential risks, contraindications, and safety measures with you during your virtual consultation.

• Major Depressive Disorder (treatment-resistant)
• PTSD and Complex Trauma
• Generalized and Social Anxiety Disorders
• Select Chronic Pain Syndromes (off-label)
• Alcoholism and Dependency Disorders

Yes, when your clinician approves it. Ketamine therapy can be paired with weight care, hormone therapy, sexual health and longevity treatments. Your clinician reviews your full list of medicines first. A second treatment takes 10% off your whole order, every month.

• Tirzepatide as a dissolvable tablet (ODT) or daily drops.
• Semaglutide + vitamin B6 as a dissolvable tablet.

Both are GLP-1 medicines, the class behind the biggest shift in weight care in decades, compounded by a licensed U.S. pharmacy into a form you take by mouth instead of by injection. A licensed clinician decides whether one is right for you and sets your dose.

Compounded medications are prepared by a licensed U.S. pharmacy for an individual patient. They are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality.

No. Ozempic®, Wegovy®, Mounjaro® and Zepbound® are FDA-approved injectable products made by Novo Nordisk and Eli Lilly. Pluto does not sell them and is not affiliated with either company.

Pluto prescribes compounded semaglutide and tirzepatide, prepared by a licensed U.S. pharmacy in a sublingual form. Compounded drugs are not FDA-approved, are not generic versions of those brands, and the FDA does not review them for safety, effectiveness or quality.

It depends on you: your starting point, your dose, how consistently you take it, and how you eat and move. Your clinician starts you on a dose and adjusts it over time.

We do not promise a number. Results reported in studies of FDA-approved injectable products do not carry over directly to compounded sublingual forms.

NAD+, glutathione and sermorelin, each as a nasal spray or a troche that dissolves in your cheek.

Looking for testosterone, estradiol, progesterone or DHEA? Those live in Hormone Therapy, with a video visit included.

Compounded medications are prepared by a licensed U.S. pharmacy for an individual patient. They are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality.

The ingredients we use have been studied, and the evidence is stronger for some than for others. We do not claim any compounded longevity treatment is proven to slow aging or extend life.

Your clinician can walk you through what is known about the one you are considering. Compounded medications are prepared by a licensed U.S. pharmacy for an individual patient. They are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality.

For most Pluto treatments, no. A licensed clinician reviews your intake and asks for labs only if something in your history calls for it.

Hormone therapy can go either way. After your video visit, your clinician decides whether you need labs. If you had labs in the last 3 to 6 months, you can upload them in your patient portal. If new labs are needed, we give you several low-cost options.

• Dissolvable tablets (ODT): compounded sildenafil, tadalafil or both, with an optional oxytocin blend. For erectile dysfunction.
• PT-141 nasal spray: a peptide that works on desire rather than blood flow. For men and women.
• Sildenafil + testosterone troche: both in one dissolving troche, taken as needed. For men. Includes a video visit.

A licensed clinician decides what fits you. Compounded medications are prepared by a licensed U.S. pharmacy for an individual patient. They are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality.

Oxytocin is a natural “bonding” hormone that enhances emotional connection, arousal, and orgasm quality.
Oxytocin works best alongside your main sexual health treatment (e.g., testosterone cream or ODT erectile support) to boost intimacy and reduce performance anxiety. It’s optional because not everyone needs that extra emotional lift, and you can use it only when you want a stronger bonding effect.

For most sexual health treatments, no. A licensed clinician reviews your intake and asks for labs only if something in your history calls for it.

Anything that contains testosterone is different. It includes a video visit, and your clinician decides whether you need labs. Recent labs (last 3 to 6 months) can be uploaded in your patient portal. If new ones are needed, we give you several low-cost options.

For him: testosterone cream, testosterone troche, and a sildenafil + testosterone troche.

For her: estradiol cream, progesterone cream and low-dose testosterone cream.

For both: DHEA cream.

Everything is prescribed only if a licensed clinician decides it is right for you. Compounded medications are prepared by a licensed U.S. pharmacy for an individual patient. They are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality.

Yes. Every hormone plan starts with a video visit with a licensed clinician, and it is included in your price. Testosterone is a controlled substance, and hormones need a real conversation about your history, your symptoms and your goals. You book it right after checkout.

Not always. After your intake and video visit, your clinician decides. Many people on low-dose therapy start without new labs.

If you had labs in the last 3 to 6 months, upload them in your patient portal. If your clinician needs new ones, we give you several low-cost options. Lab fees are not part of your plan price.

No needles, no clinic trips for shots, and a small daily dose instead of a big one every week or two. Injections usually cost less per dose, and we will not pretend otherwise. Your clinician can talk through the tradeoffs with you.

It is not for anyone who is pregnant, breastfeeding or trying to get pregnant, or men trying to father a child soon (testosterone can lower sperm count). It may not be right if you have a history of breast, uterine or prostate cancer, blood clots, stroke or heart attack. Your clinician reviews all of this at your visit and makes the call.

You get a full refund, automatically. It usually lands back on your card within 7 business days.